BRSK1 anticorps (AA 426-591) (Biotin)

N° du produit ABIN7169020

Cet anticorps anti-BRSK1 est un anticorps Lapin Polyclonal détectant BRSK1 dans ELISA. Adapté pour Humain.

Aperçu rapide pour BRSK1 anticorps (AA 426-591) (Biotin) (ABIN7169020)

Antigène: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRSK1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-BRSK1 anticorps (Biotin)

Épitope: AA 426-591

Fonction: BRSK1 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Serine/threonine-protein kinase BRSK1 protein (426-591AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BRSK1

Antigène: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Autre désignation: BRSK1

Sujet:

Background: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at \'Thr-529\' and \'Ser-579\'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at \'Ser-642\' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at \'Ser-131\', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Aliases: BR serine/threonine kinase 1 antibody, BR serine/threonine protein kinase 1 antibody, BR serine/threonine-protein kinase 1 antibody, Brain selective kinase 1 antibody, Brain-specific serine/threonine-protein kinase 1 antibody, BRSK 1 antibody, Brsk1 antibody, BRSK1_HUMAN antibody, FLJ43009 antibody, hSAD1 antibody, KIAA1811 antibody, Protein kinase SAD1A antibody, SAD 1 antibody, SAD1 antibody, SAD1 homolog antibody, SAD1 kinase antibody, SAD1A antibody, SADB antibody, SadB kinase short isoform antibody, Serine/threonine kinase SAD B antibody, Serine/threonine-protein kinase SAD-B antibody, Synapses of Amphids Defective homolog antibody

UniProt: Q8TDC3