NEK2 anticorps (AA 1-135)

N° du produit ABIN7169100

Détail du produit anti-NEK2 anticorps

Antigène: NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

Épitope: AA 1-135

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEK2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Serine/threonine-protein kinase Nek2 protein (1-135AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NEK2

Antigène: NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

Autre désignation: NEK2 (NEK2 Produits)

Synonymes: anticorps AA617254, anticorps C77054, anticorps HsPK21, anticorps NEK2A, anticorps NLK1, anticorps ATNEK2, anticorps NIMA-RELATED KINASE2, anticorps NIMA-related kinase 2, anticorps T9J14.24, anticorps T9J14_24, anticorps NIMA related kinase 2, anticorps NIMA (never in mitosis gene a)-related expressed kinase 2, anticorps NIMA-related kinase 2, anticorps NEK2, anticorps Nek2

Sujet:

Background: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC, SGOL1, NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.

Aliases: HSPK 21 antibody, HsPK21 antibody, NEK 2 antibody, NEK2 antibody, NEK2_HUMAN antibody, NEK2A antibody, Never in mitosis A-related kinase 2 antibody, NIMA (never in mitosis gene a) related kinase 2 antibody, NimA like protein kinase 1 antibody, NIMA related kinase 2 antibody, NimA related protein kinase 2 antibody, NimA-like protein kinase 1 antibody, NimA-related protein kinase 2 antibody, NLK 1 antibody, NLK1 antibody, Serine/threonine-protein kinase Nek2 antibody

UniProt: P51955

Pathways: M Phase