PLK2 anticorps (AA 336-685)

N° du produit ABIN7169161

Cet anticorps anti-PLK2 est un anticorps Lapin Polyclonal détectant PLK2 dans ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour PLK2 anticorps (AA 336-685) (ABIN7169161)

Antigène: PLK2 (Polo-Like Kinase 2 (PLK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLK2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PLK2 anticorps

Épitope: AA 336-685

Fonction: PLK2 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Serine/threonine-protein kinase PLK2 protein (336-685AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PLK2

Antigène: PLK2 (Polo-Like Kinase 2 (PLK2))

Autre désignation: PLK2

Sujet:

Background: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

Aliases: hPlk2 antibody, hSNK antibody, PLK-2 antibody, Plk2 antibody, PLK2_HUMAN antibody, Polo like kinase 2 antibody, Polo-like kinase 2 antibody, Serine/threonine protein kinase PLK2 antibody, Serine/threonine protein kinase SNK antibody, Serine/threonine-protein kinase PLK2 antibody, Serine/threonine-protein kinase SNK antibody, Serum Induced Kinase antibody, Serum-inducible kinase antibody, SNK antibody

UniProt: Q9NYY3