ULK2 anticorps (AA 211-276) (HRP)

N° du produit ABIN7169212

Cet anticorps anti-ULK2 est un anticorps Lapin Polyclonal détectant ULK2 dans ELISA. Adapté pour Humain.

Aperçu rapide pour ULK2 anticorps (AA 211-276) (HRP) (ABIN7169212)

Antigène: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULK2 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-ULK2 anticorps (HRP)

Épitope: AA 211-276

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ULK2

Antigène: ULK2 (Unc-51 Like Kinase 2 (ULK2))

Autre désignation: ULK2

Sujet:

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR, however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

Aliases: ATG1B antibody, KIAA0623 antibody, Serine/threonine protein kinase ULK2 antibody, Serine/threonine-protein kinase ULK2 antibody, ULK2 antibody, ULK2_HUMAN antibody, Unc 51 (C. elegans) like kinase 2 antibody, Unc 51 like autophagy activating kinase 2 antibody, Unc 51 like kinase 2 antibody, Unc-51-like kinase 2 antibody, Unc51.2 antibody

UniProt: Q8IYT8

Pathways: Regulation of Cell Size, Autophagy