VRK2 anticorps (AA 317-472)

N° du produit ABIN7169218

Détail du produit anti-VRK2 anticorps

Antigène: VRK2 (Vaccinia Related Kinase 2 (VRK2))

Épitope: AA 317-472

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VRK2 est non-conjugé

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase VRK2 protein (317-472AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:500-1:1000, IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VRK2

Antigène: VRK2 (Vaccinia Related Kinase 2 (VRK2))

Autre désignation: VRK2 (VRK2 Produits)

Synonymes: anticorps 2810003O05Rik, anticorps AI447698, anticorps vaccinia related kinase 2, anticorps VRK2, anticorps Vrk2

Sujet:

Background: Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates \\\'Thr-18\\\' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.

Aliases: 2810003O05Rik antibody, AI447698 antibody, EC 2.7.11.1 antibody, Serine/threonine protein kinase VRK2 antibody, Serine/threonine-protein kinase VRK2 antibody, Vaccinia related kinase 2 antibody, Vaccinia virus B1R related kinase 2 antibody, Vaccinia-related kinase 2 antibody, VRK 2 antibody, VRK2 antibody, VRK2_HUMAN antibody

UniProt: Q86Y07