WNK2 anticorps (AA 1177-1464) (Biotin)

N° du produit ABIN7169227

Cet anticorps anti-WNK2 est un anticorps Lapin Polyclonal détectant WNK2 dans ELISA. Adapté pour Humain.

Aperçu rapide pour WNK2 anticorps (AA 1177-1464) (Biotin) (ABIN7169227)

Antigène: WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNK2 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-WNK2 anticorps (Biotin)

Épitope: AA 1177-1464

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase WNK2 protein (1177-1464AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur WNK2

Antigène: WNK2 (WNK Lysine Deficient Protein Kinase 2 (WNK2))

Autre désignation: WNK2

Sujet:

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.

Aliases: WNK2 antibody, KIAA1760 antibody, PRKWNK2 antibody, SDCCAG43 antibody, P/OKcl.13 antibody, Serine/threonine-protein kinase WNK2 antibody, EC 2.7.11.1 antibody, Antigen NY-CO-43 antibody, Protein kinase lysine-deficient 2 antibody, Protein kinase with no lysine 2 antibody, Serologically defined colon cancer antigen 43 antibody

UniProt: Q9Y3S1

Pathways: Photoperiodism