WNK4 anticorps (AA 828-1106)

N° du produit ABIN7169234

Détail du produit anti-WNK4 anticorps

Antigène: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Épitope: AA 828-1106

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp WNK4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur WNK4

Antigène: WNK4 (WNK Lysine Deficient Protein Kinase 4 (WNK4))

Autre désignation: WNK4 (WNK4 Produits)

Synonymes: anticorps WNK4, anticorps PHA2B, anticorps PRKWNK4, anticorps 2010002J11Rik, anticorps Pha2b, anticorps Prkwnk4, anticorps Ac2-059, anticorps WNK lysine deficient protein kinase 4, anticorps WNK4, anticorps Wnk4

Sujet:

Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

Aliases: PHA 2B antibody, PHA2B antibody, PRKWNK 4 antibody, PRKWNK4 antibody, Protein kinase lysine deficient 4 antibody, Protein kinase lysine-deficient 4 antibody, Protein kinase with no lysine 4 antibody, Serine/threonine protein kinase WNK4 antibody, Serine/threonine-protein kinase WNK4 antibody, WNK lysine deficient protein kinase 4 antibody, Wnk4 antibody, WNK4_HUMAN antibody

UniProt: Q96J92