PP5 anticorps (AA 370-488)

N° du produit ABIN7169288

Détail du produit anti-PP5 anticorps

Antigène: PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))

Épitope: AA 370-488

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PP5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine/threonine-protein phosphatase 5 protein (370-488AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PP5

Antigène: PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))

Autre désignation: PPP5C (PPP5C Produits)

Synonymes: anticorps PP5, anticorps PPP5, anticorps PPT, anticorps AU020526, anticorps pp5, anticorps MGC89961, anticorps fc83f08, anticorps im:7146608, anticorps wu:fc83f08, anticorps zgc:110801, anticorps PPP5C, anticorps protein phosphatase 5 catalytic subunit, anticorps protein phosphatase 5, catalytic subunit, anticorps protein phosphatase 5, catalytic subunit S homeolog, anticorps serine/threonine-protein phosphatase 5, anticorps PPP5C, anticorps Ppp5c, anticorps ppp5c.S, anticorps ppp5c, anticorps LOC592155, anticorps LOC100513542, anticorps LOC100564151, anticorps LOC100186268, anticorps LOC100208775

Sujet:

Background: Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2.

Aliases: FLJ36922 antibody, FLJ55954 antibody, OTTHUMP00000165834 antibody, PP-T antibody, PP5 antibody, PPP5 antibody, PPP5_HUMAN antibody, Ppp5c antibody, PPT antibody, Protein phosphatase 5, catalytic subunit antibody, Protein phosphatase T antibody, Serine/threonine protein phosphatase 5 antibody, Serine/threonine-protein phosphatase 5 antibody

UniProt: P53041