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SH2D1A anticorps (AA 11-124) (Biotin)

SH2D1A Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7169450
  • Antigène Voir toutes SH2D1A Anticorps
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Épitope
    • 14
    • 9
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 11-124
    Reactivité
    • 50
    • 19
    • 19
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 46
    • 3
    • 1
    • 1
    Lapin
    Clonalité
    • 49
    • 2
    Polyclonal
    Conjugué
    • 24
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SH2D1A est conjugé à/à la Biotin
    Application
    • 47
    • 19
    • 13
    • 4
    • 4
    • 4
    • 2
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human SH2 domain-containing protein 1A protein (11-124AA)
    Isotype
    IgG
    Top Product
    Discover our top product SH2D1A Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    SH2D1A (SH2 Domain Containing 1A (SH2D1A))
    Autre désignation
    SH2D1A (SH2D1A Produits)
    Synonymes
    anticorps DSHP, anticorps EBVS, anticorps IMD5, anticorps LYP, anticorps MTCP1, anticorps SAP, anticorps SAP/SH2D1A, anticorps XLP, anticorps XLPD, anticorps RGD1562408, anticorps Gm686, anticorps SH2D1A, anticorps SH2 domain containing 1A, anticorps SH2D1A, anticorps Sh2d1a
    Sujet

    Background: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

    Aliases: DSHP antibody, Duncan disease SH2 protein antibody, Duncan disease SH2-protein antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, SH2 domain containing 1A antibody, SH2 domain protein 1A antibody, SH2 domain-containing protein 1A antibody, SH21A_HUMAN antibody, SH2D1A antibody, Signaling lymphocyte activation molecule associated protein antibody, Signaling lymphocytic activation molecule-associated protein antibody, SLAM associated protein antibody, SLAM associated protein/SH2 domain protein 1A antibody, SLAM-associated protein antibody, T cell signal transduction molecule SAP antibody, T-cell signal transduction molecule SAP antibody, XLP antibody, XLPD antibody

    UniProt
    O60880
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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