SPPL3 anticorps (AA 213-263)

N° du produit ABIN7169631

Détail du produit anti-SPPL3 anticorps

Antigène: SPPL3 (Signal Peptide Peptidase 3 (SPPL3))

Épitope: AA 213-263

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPPL3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:200-1:2000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SPPL3

Antigène: SPPL3 (Signal Peptide Peptidase 3 (SPPL3))

Autre désignation: SPPL3 (SPPL3 Produits)

Synonymes: anticorps CG17370, anticorps CG5901, anticorps Dmel\\CG17370, anticorps SPPL3, anticorps Sppl, anticorps sppL, anticorps RGD1562826, anticorps Sppl3-ps1, anticorps MGC52975, anticorps sppl3, anticorps MGC75937, anticorps fb94d08, anticorps wu:fb94d08, anticorps zgc:114093, anticorps 4833416I09Rik, anticorps Psl4, anticorps Usmg3, anticorps IMP2, anticorps MDHV1887, anticorps PRO4332, anticorps PSH1, anticorps PSL4, anticorps Signal peptide peptidase-like, anticorps signal peptide peptidase like 3, anticorps signal peptide peptidase like 3 L homeolog, anticorps signal peptide peptidase 3, anticorps Intramembrane protease 2, anticorps SppL, anticorps Sppl3, anticorps sppl3.L, anticorps sppl3, anticorps SPPL3, anticorps imp-2

Sujet:

Background: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).

Aliases: SPPL3 antibody, IMP2 antibody, PSL4 antibody, Signal peptide peptidase-like 3 antibody, SPP-like 3 antibody, EC 3.4.23.- antibody, Intramembrane protease 2 antibody, IMP-2 antibody, Presenilin homologous protein 1 antibody, PSH1 antibody, Presenilin-like protein 4 antibody

UniProt: Q8TCT6