SNX5 anticorps (AA 7-245) (HRP)

N° du produit ABIN7170401

Cet anticorps Lapin Polyclonal détecte spécifiquement SNX5 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour SNX5 anticorps (AA 7-245) (HRP) (ABIN7170401)

Antigène: SNX5 (Sorting Nexin 5 (SNX5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNX5 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-SNX5 anticorps (HRP)

Épitope: AA 7-245

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Sorting nexin-5 protein (7-245AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SNX5

Antigène: SNX5 (Sorting Nexin 5 (SNX5))

Autre désignation: SNX5

Sujet:

Background: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation, the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941).

Aliases: 0910001N05Rik antibody, 1810032P22Rik antibody, AU019504 antibody, D2Ertd52e antibody, FLJ10931 antibody, OTTHUMP00000030340 antibody, OTTHUMP00000062927 antibody, OTTMUSP00000003367 antibody, OTTMUSP00000003368 antibody, RP11-504H3.2 antibody, RP23-35E16.2 antibody, snoRNA MBI-43 antibody, SNX 5 antibody, SNX5 antibody, SNX5_HUMAN antibody, Sorting nexin 5 antibody, Sorting nexin-5 antibody

UniProt: Q9Y5X3