SNX6 anticorps (AA 1-290) (Biotin)

N° du produit ABIN7170403

Cet anticorps anti-SNX6 est un anticorps Lapin Polyclonal détectant SNX6 dans ELISA. Adapté pour Humain.

Aperçu rapide pour SNX6 anticorps (AA 1-290) (Biotin) (ABIN7170403)

Antigène: SNX6 (Sorting Nexin 6 (SNX6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SNX6 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-SNX6 anticorps (Biotin)

Épitope: AA 1-290

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Sorting nexin-6 protein (1-290AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SNX6

Antigène: SNX6 (Sorting Nexin 6 (SNX6))

Autre désignation: SNX6

Sujet:

Background: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).

Aliases: SNX6 antibody, Sorting nexin-6 antibody, TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6 antibody, N-terminally processed] antibody

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway