SKA1 anticorps (AA 61-134)

N° du produit ABIN7170587

Détail du produit anti-SKA1 anticorps

Antigène: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Épitope: AA 61-134

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKA1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Spindle and kinetochore-associated protein 1 protein (61-134AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SKA1

Antigène: SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))

Autre désignation: SKA1 (SKA1 Produits)

Synonymes: anticorps C18H18orf24, anticorps C18orf24, anticorps 2810433K01Rik, anticorps AV117428, anticorps RGD1310784, anticorps spindle and kinetochore associated complex subunit 1, anticorps SKA1, anticorps ska1, anticorps Ska1

Sujet:

Background: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).

Aliases: 2810433K01Rik antibody, AV117428 antibody, C18orf24 antibody, MGC10200 antibody, Ska1 antibody, SKA1_HUMAN antibody, Spindle and kinetochore associated complex subunit 1 antibody, Spindle and kinetochore associated protein 1 antibody, Spindle and kinetochore-associated protein 1 antibody, Spindle and KT (kinetochore) associated 1 antibody, Spindle and KT associated 1 antibody

UniProt: Q96BD8

Pathways: M Phase