TSPAN12 anticorps (AA 111-224) (FITC)

N° du produit ABIN7171848

L’anticorps Lapin Polyclonal anti-TSPAN12 a été validé pour . Il convient pour détecter TSPAN12 dans des échantillons de Humain.

Aperçu rapide pour TSPAN12 anticorps (AA 111-224) (FITC) (ABIN7171848)

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TSPAN12 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-TSPAN12 anticorps (FITC)

Épitope: AA 111-224

Fonction: TSPAN12 Antibody, FITC conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Tetraspanin-12 protein (111-224AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TSPAN12

Antigène: TSPAN12 (Tetraspanin 12 (TSPAN12))

Autre désignation: TSPAN12

Sujet:

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Aliases: TSPAN12 antibody, NET2 antibody, TM4SF12 antibody, UNQ774/PRO1568Tetraspanin-12 antibody, Tspan-12 antibody, Tetraspan NET-2 antibody, Transmembrane 4 superfamily member 12 antibody

UniProt: O95859