THO Complex 4 anticorps (AA 186-240) (Biotin)

N° du produit ABIN7172056

Cet anticorps anti-THO Complex 4 est un anticorps Lapin Polyclonal détectant THO Complex 4 dans ELISA. Adapté pour Humain.

Aperçu rapide pour THO Complex 4 anticorps (AA 186-240) (Biotin) (ABIN7172056)

Antigène: THO Complex 4 (THOC4)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THO Complex 4 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-THO Complex 4 anticorps (Biotin)

Épitope: AA 186-240

Fonction: ALYREF Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human THO complex subunit 4 protein (186-240AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur THO Complex 4

Antigène: THO Complex 4 (THOC4)

Autre désignation: ALYREF

Sujet:

Background: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5\\\' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi\\\'s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production, ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA, proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.

Aliases: Ally of AML-1 and LEF-1 antibody, Ally of AML1 and LEF1 antibody, ALY antibody, ALY/REF antibody, Aly/REF export factor antibody, BEF antibody, bZIP enhancing factor antibody, bZIP-enhancing factor BEF antibody, REF antibody, THO complex 4 antibody, THO complex subunit 4 antibody, Tho4 antibody, thoc4 antibody, THOC4_HUMAN antibody, Transcriptional coactivator Aly/REF antibody, Transcriptional coactivator antibody

UniProt: Q86V81