MAF anticorps (AA 55-180)

N° du produit ABIN7172574

L’anticorps Lapin Polyclonal anti-MAF a été validé pour ELISA et IHC. Il convient pour détecter MAF dans des échantillons de Humain.

Aperçu rapide pour MAF anticorps (AA 55-180) (ABIN7172574)

Antigène: MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAF est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-MAF anticorps

Épitope: AA 55-180

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Transcription factor Maf protein (55-180AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAF

Antigène: MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))

Autre désignation: MAF

Sujet:

Background: Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5\'-[GT]G[GC]N[GT]NCTCAGNN-3\' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters.

Aliases: AS42 oncogene homolog antibody, Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene antibody, Avian musculoaponeurotic fibrosarcoma (v maf) antibody, c maf proto oncogene antibody, cMaf antibody, maf antibody, MAF_HUMAN antibody, MAF2 antibody, MGC71685 antibody, Proto oncogene c Maf antibody, Proto-oncogene c-maf antibody, Transcription factor Maf antibody, v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) antibody, v maf musculoaponeurotic fibrosarcoma oncogene homolog antibody, V-maf musculoaponeurotic fibrosarcoma oncogene homolog antibody

UniProt: O75444