LRRC32 anticorps (AA 301-500)

N° du produit ABIN7172807

Cet anticorps Lapin Polyclonal détecte spécifiquement LRRC32 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour LRRC32 anticorps (AA 301-500) (ABIN7172807)

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRRC32 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-LRRC32 anticorps

Épitope: AA 301-500

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Transforming growth factor beta activator LRRC32 protein (301-500AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LRRC32

Antigène: LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))

Autre désignation: LRRC32

Sujet:

Background: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity).

Aliases: D11S833E antibody, GARP antibody, Garpin antibody, Glycoprotein A repetitions predominant antibody, Leucine rich repeat containing 32 antibody, Leucine-rich repeat-containing protein 32 antibody, LRC32_HUMAN antibody, LRRC32 antibody

UniProt: Q14392

Pathways: Activated T Cell Proliferation