TGFB3 anticorps (AA 301-412)

N° du produit ABIN7172834

Cet anticorps Lapin Polyclonal détecte spécifiquement TGFB3 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour TGFB3 anticorps (AA 301-412) (ABIN7172834)

Antigène: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TGFB3 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-TGFB3 anticorps

Épitope: AA 301-412

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Transforming growth factor beta-3 proprotein protein (301-412AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:50-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TGFB3

Antigène: TGFB3 (Transforming Growth Factor, beta 3 (TGFB3))

Autre désignation: TGFB3

Sujet:

Background: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.Latency-associated peptide: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with \\\'milieu molecules\\\', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3.Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with \\\'milieu molecules\\\', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).

Aliases: ARVD antibody, ARVD1 antibody, FLJ16571 antibody, LDS5 antibody, MGC105479 antibody, MGC118722 antibody, prepro-transforming growth factor beta-3 antibody, RNHF antibody, TGF beta 3 antibody, TGF beta3 antibody, TGF-beta-3 antibody, TGFB 3 antibody, Tgfb3 antibody, TGFB3_HUMAN antibody, transforming growth factor beta 3 antibody, Transforming growth factor beta-3 antibody

UniProt: P10600

Pathways: Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus