TBCD anticorps (AA 2-96)

N° du produit ABIN7173750

L’anticorps Lapin Polyclonal anti-TBCD a été validé pour ELISA, IF et IHC. Il convient pour détecter TBCD dans des échantillons de Humain.

Aperçu rapide pour TBCD anticorps (AA 2-96) (ABIN7173750)

Antigène: TBCD (Tubulin Folding Cofactor D (TBCD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TBCD est non-conjugé

Application: ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-TBCD anticorps

Épitope: AA 2-96

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tubulin-specific chaperone D protein (2-96AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur TBCD

Antigène: TBCD (Tubulin Folding Cofactor D (TBCD))

Autre désignation: TBCD

Sujet:

Background: Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (PubMed:10722852, PubMed:10831612, PubMed:11847227, PubMed:20740604, PubMed:27666370, PubMed:28158450). Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis (PubMed:27666370). Involved in neuron morphogenesis (PubMed:27666374).

Aliases: Beta tubulin cofactor D antibody, Beta-tubulin cofactor D antibody, KIAA0988 antibody, SSD 1 antibody, SSD-1 antibody, SSD1 antibody, tbcd antibody, TBCD_HUMAN antibody, tfcD antibody, Tubulin folding cofactor D antibody, Tubulin specific chaperone D antibody, Tubulin-folding cofactor D antibody, Tubulin-specific chaperone D antibody

UniProt: Q9BTW9

Pathways: Cell-Cell Junction Organization