ABL2 anticorps (AA 862-1064) (Biotin)

N° du produit ABIN7174006

Cet anticorps anti-ABL2 est un anticorps Lapin Polyclonal détectant ABL2 dans ELISA. Adapté pour Humain.

Aperçu rapide pour ABL2 anticorps (AA 862-1064) (Biotin) (ABIN7174006)

Antigène: ABL2

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL2 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-ABL2 anticorps (Biotin)

Épitope: AA 862-1064

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Tyrosine-protein kinase ABL2 protein (862-1064AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ABL2

Antigène: ABL2

Autre désignation: ABL2

Sujet:

Background: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement), CTTN (involved in signaling), or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Aliases: Abelson murine leukemia viral oncogene homolog 2 antibody, Abelson related gene protein antibody, Abelson tyrosine-protein kinase 2 antibody, Abelson-related gene protein antibody, ABL2 antibody, ABL2_HUMAN antibody, ABLL antibody, ARG antibody, Tyrosine kinase ARG antibody, Tyrosine protein kinase ABL2 antibody, Tyrosine-protein kinase ARG antibody, v abl Abelson murine leukemia viral oncogene homolog 2 antibody

UniProt: P42684