Ubiquilin 2 anticorps (AA 473-542)

N° du produit ABIN7174228

Cet anticorps anti-Ubiquilin 2 est un anticorps Lapin Polyclonal détectant Ubiquilin 2 dans ELISA, IHC et IF. Adapté pour Humain.

Aperçu rapide pour Ubiquilin 2 anticorps (AA 473-542) (ABIN7174228)

Antigène: Ubiquilin 2 (UBQLN2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubiquilin 2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Ubiquilin 2 anticorps

Épitope: AA 473-542

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquilin-2 protein (473-542AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Ubiquilin 2

Antigène: Ubiquilin 2 (UBQLN2)

Autre désignation: UBQLN2

Sujet:

Background: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation, required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).

Aliases: UBQLN2 antibody, N4BP4 antibody, PLIC2 antibody, HRIHFB2157Ubiquilin-2 antibody, Chap1 antibody, DSK2 homolog antibody, Protein linking IAP with cytoskeleton 2 antibody, PLIC-2 antibody, hPLIC-2 antibody, Ubiquitin-like product Chap1/Dsk2 antibody

UniProt: Q9UHD9