USP1 anticorps (AA 453-592)

N° du produit ABIN7174250

Cet anticorps Lapin Polyclonal détecte spécifiquement USP1 dans WB, ELISA, IHC, IP et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour USP1 anticorps (AA 453-592) (ABIN7174250)

Antigène: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Détail du produit anti-USP1 anticorps

Épitope: AA 453-592

Réactivité croisée: Humain, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquitin carboxyl-terminal hydrolase 10 protein (453-592AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur USP1

Antigène: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Autre désignation: USP1

Sujet:

Background: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).

Aliases: Deubiquitinating enzyme 10 antibody, KIAA0190 antibody, MGC124997 antibody, MGC2621 antibody, Ubiquitin carboxyl terminal hydrolase 10 antibody, Ubiquitin carboxyl-terminal hydrolase 10 antibody, Ubiquitin specific peptidase 10 antibody, Ubiquitin specific processing protease 10 antibody, Ubiquitin specific protease 10 antibody, Ubiquitin thioesterase 10 antibody, Ubiquitin thiolesterase 10 antibody, Ubiquitin-specific-processing protease 10 antibody, UBP10_HUMAN antibody, UBPO antibody, USP 10 antibody, USP10 antibody

UniProt: Q14694