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OTUB1 anticorps (AA 2-201)

OTUB1 Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7174393
  • Antigène Voir toutes OTUB1 Anticorps
    OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
    Épitope
    • 15
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 2-201
    Reactivité
    • 55
    • 29
    • 16
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    Humain
    Hôte
    • 59
    • 7
    • 1
    Lapin
    Clonalité
    • 59
    • 8
    Polyclonal
    Conjugué
    • 31
    • 10
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp OTUB1 est non-conjugé
    Application
    • 56
    • 16
    • 16
    • 13
    • 13
    • 9
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Ubiquitin thioesterase OTUB1 protein (2-201AA)
    Isotype
    IgG
    Top Product
    Discover our top product OTUB1 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))
    Autre désignation
    OTUB1 (OTUB1 Produits)
    Synonymes
    anticorps OTB1, anticorps OTU1, anticorps AI850305, anticorps fa19h07, anticorps otub1, anticorps wu:fa19h07, anticorps zgc:92839, anticorps MGC131231, anticorps fb17f04, anticorps otub1l, anticorps wu:fb17f04, anticorps zgc:92685, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1, anticorps OTU domain, ubiquitin aldehyde binding 1, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1b, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1 L homeolog, anticorps similar to HSPC263, anticorps OTU deubiquitinase, ubiquitin aldehyde binding 1a, anticorps OTUB1, anticorps Otub1, anticorps otub1b, anticorps otub1.L, anticorps otub1, anticorps RGD1565010, anticorps otub1a
    Sujet

    Background: Hydrolase that can specifically remove \\\'Lys-48\\\'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL, a crucial inductor of CD4 T-cell anergy. Isoform 1 destabilizes RNF128, leading to prevent anergy. In contrast, isoform 2 stabilizes RNF128 and promotes anergy. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha (ESR1). Mediates deubiquitination of \\\'Lys-48\\\'-linked polyubiquitin chains, but not \\\'Lys-63\\\'-linked polyubiquitin chains. Not able to cleave di-ubiquitin. Also capable of removing NEDD8 from NEDD8 conjugates, but with a much lower preference compared to \\\'Lys-48\\\'-linked ubiquitin. Plays a key non-catalytic role in DNA repair regulation by inhibiting activity of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of \\\'Lys-63\\\'-linked histone H2A and H2AX at DNA damage sites. Inhibits RNF168 independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N/UBC13, the E2 partner of RNF168, thereby limiting spreading of \\\'Lys-63\\\'-linked histone H2A and H2AX marks. Inhibition occurs by binding to free ubiquitin: free ubiquitin acts as an allosteric regulator that increases affinity for UBE2N/UBC13 and disrupts interaction with UBE2V1. The OTUB1-UBE2N/UBC13-free ubiquitin complex adopts a configuration that mimics a cleaved \\\'Lys48\\\'-linked di-ubiquitin chain.

    Aliases: Deubiquitinating enzyme OTUB1 antibody, hOTU1 antibody, HSPC263 antibody, OTB1 antibody, OTU domain containing ubiquitin aldehyde binding protein 1 antibody, OTU domain, ubiquitin aldehyde binding 1 antibody, OTU domain-containing Ubal-binding protein 1 antibody, OTU domain-containing ubiquitin aldehyde-binding protein 1 antibody, OTU-domain Ubal-binding 1 antibody, OTU1 antibody, Otub1 antibody, OTUB1_HUMAN antibody, Otubain 1 antibody, Otubain-1 antibody, Ubiquitin specific processing protease OTUB1 antibody, Ubiquitin thioesterase OTUB1 antibody, ubiquitin-specific protease otubain 1 antibody, Ubiquitin-specific-processing protease OTUB1 antibody

    UniProt
    Q96FW1
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