RUNX2 anticorps (pSer451)

N° du produit ABIN713231

Détail du produit anti-RUNX2 anticorps

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Épitope: pSer451

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUNX2 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Réactivité croisée: Humain

Homologie: Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human RUNX2 around the phosphorylation site of Ser451

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RUNX2

Antigène: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Autre désignation: RUNX2 (RUNX2 Produits)

Synonymes: anticorps AML3, anticorps CBF-alpha-1, anticorps CBFA1, anticorps CCD, anticorps CCD1, anticorps CLCD, anticorps OSF-2, anticorps OSF2, anticorps PEA2aA, anticorps PEBP2aA, anticorps Cbf, anticorps Cbfa-1, anticorps Cbfa1, anticorps LS3, anticorps Osf2, anticorps Pebp2a1, anticorps Pebpa2a, anticorps runx2, anticorps RUNX2, anticorps ccd, anticorps aml3, anticorps ccd1, anticorps osf2, anticorps cbfa1, anticorps pea2aa, anticorps pebp2a1, anticorps pebp2a2, anticorps pebp2aa, anticorps pebp2aa1, anticorps runt related transcription factor 2, anticorps runt-related transcription factor 2a, anticorps runt-related transcription factor 2, anticorps runt related transcription factor 2 L homeolog, anticorps RUNX2, anticorps runx2a, anticorps Runx2, anticorps runx2, anticorps LOC703331, anticorps LOC100549663, anticorps runx2.L

Sujet:

Synonyms: CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1, Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, RUNX2, PEBP2A

Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

ID gène: 860

UniProt: Q13950