ube3a anticorps (AA 83-234)

N° du produit ABIN7174571

Détail du produit anti-ube3a anticorps

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Épitope: AA 83-234

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ube3a est non-conjugé

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Ubiquitin-protein ligase E3A protein (83-234AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ube3a

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Autre désignation: UBE3A (ube3a Produits)

Synonymes: anticorps ANCR, anticorps AS, anticorps E6-AP, anticorps EPVE6AP, anticorps HPVE6A, anticorps DDBDRAFT_0188760, anticorps DDBDRAFT_0302447, anticorps DDB_0188760, anticorps DDB_0302447, anticorps ube3a, anticorps im:7140733, anticorps zgc:92173, anticorps 4732496B02, anticorps 5830462N02Rik, anticorps A130086L21Rik, anticorps Hpve6a, anticorps mKIAA4216, anticorps As, anticorps CG6190, anticorps Dmel\\CG6190, anticorps Dube3a, anticorps UBE3A, anticorps dUBE3A, anticorps das, anticorps dube3A, anticorps dube3a, anticorps MGC69536, anticorps UME3A, anticorps ubiquitin protein ligase E3A, anticorps ubiquitin-protein ligase E3A, anticorps Ubiquitin protein ligase E3A, anticorps ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog, anticorps ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome), anticorps UBE3A, anticorps ube3a, anticorps LOC100194730, anticorps Ube3a, anticorps ube3a.S, anticorps Eint_040430

Sujet:

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).

Aliases: ANCR antibody, Angelman syndrome antibody, AS antibody, CTCL tumor antigen se37 2 antibody, CTCL tumor antigen se37-2 antibody, E6 AP antibody, E6AP antibody, E6AP ubiquitin protein ligase antibody, E6AP ubiquitin-protein ligase antibody, EPVE6AP antibody, FLJ26981 antibody, HECT-type ubiquitin transferase E3A antibody, HPVE6A antibody, Human papilloma virus E6 associated protein Angelman syndrome antibody, Human papilloma virus E6 associated protein antibody, Human papillomavirus E6-associated protein antibody, NY REN 54 antigen antibody, Oncogenic protein associated protein E6 AP antibody, Oncogenic protein associated protein E6AP antibody, Oncogenic protein-associated protein E6-AP antibody, Renal carcinoma antigen NY REN 54 antibody, Renal carcinoma antigen NY-REN-54 antibody, UBE 3A antibody, Ube3a antibody, UBE3A protein antibody, UBE3A_HUMAN antibody, Ubiquitin protein ligase E3A antibody, Ubiquitin-protein ligase E3A antibody

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway