Villin 1 anticorps (AA 1-350)

N° du produit ABIN7175510

Cet anticorps Lapin Polyclonal détecte spécifiquement Villin 1 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour Villin 1 anticorps (AA 1-350) (ABIN7175510)

Antigène: Villin 1 (VIL1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Villin 1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-Villin 1 anticorps

Épitope: AA 1-350

Fonction: VIL1 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Villin-1 protein (1-350AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Villin 1

Antigène: Villin 1 (VIL1)

Autre désignation: VIL1

Sujet:

Background: Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA), binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

Aliases: D2S1471 antibody, OTTHUMP00000164145 antibody, VIL antibody, VIL1 antibody, VILI_HUMAN antibody, Villin 1 antibody, Villin-1 antibody, Villin1 antibody

UniProt: P09327

Pathways: EGFR Signaling Pathway, Regulation of Actin Filament Polymerization