XAF1 anticorps (AA 172-259)

N° du produit ABIN7175921

Cet anticorps Lapin Polyclonal détecte spécifiquement XAF1 dans ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour XAF1 anticorps (AA 172-259) (ABIN7175921)

Antigène: XAF1 (XiAP Associated Factor 1 (XAF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XAF1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-XAF1 anticorps

Épitope: AA 172-259

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human XIAP-associated factor 1 protein (172-259AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur XAF1

Antigène: XAF1 (XiAP Associated Factor 1 (XAF1))

Autre désignation: XAF1

Sujet:

Background: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

Aliases: BIRC 4 binding protein antibody, BIRC4 binding protein antibody, BIRC4-binding protein antibody, BIRC4BP antibody, HSXIAPAF 1 antibody, HSXIAPAF1 antibody, XAF 1 antibody, XAF1 antibody, XAF1_HUMAN antibody, XIAP associated factor 1 antibody, XIAP-associated factor 1 antibody, XIAPAF1 antibody

UniProt: Q6GPH4