YTHDC1 anticorps (AA 89-153)

N° du produit ABIN7175950

Détail du produit anti-YTHDC1 anticorps

Antigène: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Épitope: AA 89-153

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YTHDC1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human YTH domain-containing protein 1 protein (89-153AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur YTHDC1

Antigène: YTHDC1 (YTH Domain Containing 1 (YTHDC1))

Autre désignation: YTHDC1 (YTHDC1 Produits)

Synonymes: anticorps C80342, anticorps mKIAA1966, anticorps A730098D12Rik, anticorps zgc:101592, anticorps MGC89461, anticorps MGC137509, anticorps DKFZp459L1228, anticorps YT521, anticorps YT521-B, anticorps Yt521, anticorps YTH domain containing 1, anticorps YTH domain containing 1 L homeolog, anticorps Ythdc1, anticorps YTHDC1, anticorps ythdc1, anticorps ythdc1.L

Sujet:

Background: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).

Aliases: YTHDC1 antibody, KIAA1966 antibody, YT521 antibody, YTH domain-containing protein 1 antibody, Splicing factor YT521 antibody, YT521-B antibody

UniProt: Q96MU7