SUV39H1 anticorps (AA 211-310)

N° du produit ABIN713561

L’anticorps Lapin Polyclonal anti-SUV39H1 a été validé pour ELISA, IF (cc), IF (p), IHC (p) et IHC (fro). Il convient pour détecter SUV39H1 dans des échantillons de Humain.

Aperçu rapide pour SUV39H1 anticorps (AA 211-310) (ABIN713561)

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUV39H1 est non-conjugé

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-SUV39H1 anticorps

Épitope: AA 211-310

Homologie: Human,Mouse,Rat,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Histone-lysine N-methyltransferase SUV39H1

Isotype: IgG

Information d'application

Indications d'application: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur SUV39H1

Antigène: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Autre désignation: SUV39H1

Sujet:

Synonyms: H3 K9 HMTase, H3 K9 HMTase1, H3-K9-HMTase 1, Histone H3 K9 methylation, Histone H3 Lys 9 methylation, Histone H3-K9 methyltransferase 1, Histone H3-K9 methyltransferase1, Histone lysine N methyltransferase H3 lysine 9 specic 1, Histone lysine N methyltransferase, H3 lysine 9 specic 1, Histone-lysine N-methyltransferase SUV39H1, KMT1 A, Lysine N methyltransferase 1A, Lysine N-methyltransferase 1A, MG44, mIS6, Position-effect variegation 3-9 homolog, Suvar3 9 homolog 1, Suvar3-9 homolog 1, Suppressor of variegation 3 9 homolog 1 Drosophila, Suppressor of variegation 3-9 homolog 1, SUV39 H1, SUV39H, SUV39H1, SUV91_HUMAN.

Background: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.

ID gène: 6839