ABCC4 anticorps

N° du produit ABIN7178642

Cet anticorps Lapin Polyclonal détecte spécifiquement ABCC4 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour ABCC4 anticorps (ABIN7178642)

Antigène: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCC4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ABCC4 anticorps

Fonction: ABCC4 Antibody

Réactivité croisée: Souris, Rat

Purification: Affinity purification

Immunogène: Recombinant protein of Human ABCC4

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ABCC4

Antigène: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Autre désignation: ABCC4

Sujet:

Background: ABCC4 is a member of the ATP-binding Cassette (ABC) transporter family. ABC proteins transport various molecules across cellular membranes by utilizing the energy generated from ATP hydrolysis. There are seven subfamilies of ABC proteins: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. ABCC4 belongs to the MRP subfamily, which is involved in multi-drug resistance, hence it is also named MRP4. ABCC4 is widely expressed in cells and tissues including prostate, kidney proximal tubules, astrocytes and capillary endothelial cells of the brain, platelets, and many cancer cell lines. ABCC4 mediates efflux transport of a wide variety of endogenous and xenobiotic organic anionic compounds. The diversity of substrates determines the biological functions of ABCC4. It regulates cAMP levels in human leukemia cells, thereby controlling the proliferation and differentiation of leukemia cells. ABCC4 also enables COX deficient pancreatic cancer cells to obtain exogenous prostagladins. Researchers have shown that ABCC4 expression is elevated in drug resistant cancer cells, which makes it a potential target for cancer therapy . ABCC4 localizes to both plasma membrane and intracellular membranous structures. Investigators have also implicated ABCC4 in the pathogenesis of Kawasaki desease, a genetic childhood disease characterized by vasculitis.

Aliases: ABCC 4 antibody, ABCC4 antibody, ATP binding cassette sub family C (CFTR/MRP) member 4 antibody, ATP binding cassette sub family C member 4 antibody, ATP-binding cassette sub-family C member 4 antibody, bA464I2.1 (ATP binding cassette, sub-family C (CFTR/MRP) member 4) antibody, bA464I2.1 antibody, Canalicular multispecific organic anion transporter antibody, Canalicular multispecific organic anion transporter ABC superfamily antibody, EST170205 antibody, MOAT B antibody, MOAT-B antibody, MOATB antibody, MRP 4 antibody, MRP/cMOAT related ABC transporter antibody, MRP/cMOAT-related ABC transporter antibody, MRP4_HUMAN antibody, Multi specific organic anion transporter B antibody, Multi-specific organic anion transporter B antibody, Multidrug resistance associated protein 4 antibody, Multidrug resistance-associated protein 4 antibody, OTTHUMP00000018560 antibody

UniProt: O15439