KNG1 anticorps (AA 2-110) (Biotin)

N° du produit ABIN7178918

Cet anticorps Lapin Polyclonal détecte spécifiquement KNG1 dans ELISA. Il présente une réactivité envers Rat.

Aperçu rapide pour KNG1 anticorps (AA 2-110) (Biotin) (ABIN7178918)

Antigène: KNG1 (Kininogen 1 (KNG1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KNG1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-KNG1 anticorps (Biotin)

Épitope: AA 2-110

Fonction: Kng1 Antibody, Biotin conjugated

Réactivité croisée: Rat

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Rat Kininogen-1 protein (2-110AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KNG1

Antigène: KNG1 (Kininogen 1 (KNG1))

Autre désignation: Kng1

Sujet:

Background: Kininogens are inhibitors of thiol proteases, (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes, (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action), (5) LMW-kininogen inhibits the aggregation of thrombocytes, (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Aliases: Kng1 antibody, Kng antibody, Kininogen-1 [Cleaved into: Kininogen-1 heavy chain, Bradykinin, Kininogen-1 light chain] antibody

UniProt: P08934

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process