VP35 (AA 1-329) anticorps (FITC)

N° du produit ABIN7179137

Détail du produit

Antigène: VP35

Épitope: AA 1-329

Reactivité: Reston Ebola virus

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: FITC

Application: Veuillez nous consulter SVP

Réactivité croisée: Reston Ebola virus

Purification: >95%, Protein G purified

Immunogène: Recombinant Reston ebolavirus Polymerase cofactor VP35 protein (1-329AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: VP35

Sujet:

Background: Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.

Aliases: VP35 antibody, Polymerase cofactor VP35 antibody

UniProt: Q91DE0