Simian Immunodeficiency Virus (Isolate K78) (SIV-Mac) (Simian Immunodeficiency Virus Rhesus Monkey) Vpx (AA 1-112) anticorps (FITC)

N° du produit ABIN7179350

Cet anticorps Lapin Polyclonal détecte spécifiquement dans . Il présente une réactivité envers Simian Immunodeficiency Virus (SIV).

Aperçu rapide pour Simian Immunodeficiency Virus (Isolate K78) (SIV-Mac) (Simian Immunodeficiency Virus Rhesus Monkey) Vpx (AA 1-112) anticorps (FITC) (ABIN7179350)

Antigène: Simian Immunodeficiency Virus (Isolate K78) (SIV-Mac) (Simian Immunodeficiency Virus Rhesus Monkey) Vpx

Reactivité: Simian Immunodeficiency Virus (SIV)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: FITC

Détail du produit

Épitope: AA 1-112

Virus Strain: isolate K78

Fonction: vpx Antibody, FITC conjugated

Réactivité croisée: Simian Immunodeficiency Virus (SIV)

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Simian Immunodeficiency Virus (Isolate K78) (SIV-Mac) (Simian Immunodeficiency Virus Rhesus Monkey) Vpx

Sujet:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P11266