CADM1 anticorps (C-Term)

N° du produit ABIN7180134

L’anticorps Lapin Polyclonal anti-CADM1 a été validé pour WB et ELISA. Il convient pour détecter CADM1 dans des échantillons de Humain.

Aperçu rapide pour CADM1 anticorps (C-Term) (ABIN7180134)

Antigène: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CADM1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CADM1 anticorps

Épitope: C-Term

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human CADM1.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CADM1

Antigène: CADM1 (Cell Adhesion Molecule 1 (CADM1))

Autre désignation: CADM1

Sujet:

Background: Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly By similarity. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. UniProtKB Q8R5M8

Zhou Y., Biochim. Biophys. Acta 1669:142-154(2005).
Ota T., Nat. Genet. 36:40-45(2004).
Kuramochi M., Nat. Genet. 27:427-430(2001).

Aliases: BL2 antibody, Cadm1 antibody, CADM1_HUMAN antibody, Cell adhesion molecule 1 antibody, DKFZp686F1789 antibody, IgSF4 antibody, IGSF4A antibody, Immunoglobulin superfamily member 4 antibody, MGC149785 antibody, MGC51880 antibody, NECL-2 antibody, NECL2 antibody, Nectin like 2 antibody, Nectin-like protein 2 antibody, RA175 antibody, SgIGSF antibody, Spermatogenic immunoglobulin superfamily antibody, ST17 antibody, sTSLC 1 antibody, Synaptic cell adhesion molecule antibody, SynCAM antibody, SynCAM1 antibody, TSLC-1 antibody, TSLC1 antibody, Tumor suppressor in lung cancer 1 antibody

UniProt: Q9BY67

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Activated T Cell Proliferation