CLNS1A anticorps (C-Term)

N° du produit ABIN7180144

Cet anticorps anti-CLNS1A est un anticorps Lapin Polyclonal détectant CLNS1A dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour CLNS1A anticorps (C-Term) (ABIN7180144)

Antigène: CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLNS1A est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CLNS1A anticorps

Épitope: C-Term

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human CLNS1A.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CLNS1A

Antigène: CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))

Autre désignation: CLNS1A

Sujet:

Background: Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.

Buyse G., Biochem. Biophys. Res. Commun. 218:822-827(1996).
Anquita J., Biochem. Biophys. Res. Commun. 208:89-95(1995).
Lamb F.S., Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.

Aliases: Chloride channel antibody, Chloride channel nucleotide sensitive 1A antibody, Chloride channel regulatory protein antibody, Chloride conductance regulator, volume sensitive antibody, Chloride conductance regulatory protein ICln antibody, Chloride ion current inducer protein antibody, ClCI antibody, CLNS 1A antibody, Clns1a antibody, CLNS1B antibody, I(Cln) antibody, ICln antibody, ICLN_HUMAN antibody, Methylosome subunit pICln antibody, nucleotide sensitive 1A antibody, Reticulocyte pICln antibody, Reticulocyte protein ICln antibody

UniProt: P54105

Pathways: Ribonucleoprotein Complex Subunit Organization