KSR2 anticorps

N° du produit ABIN7183716

Détail du produit anti-KSR2 anticorps

Antigène: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KSR2 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human KSR2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IF:1:100-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KSR2

Antigène: KSR2 (Kinase Suppressor of Ras 2 (KSR2))

Autre désignation: KSR2 (KSR2 Produits)

Synonymes: anticorps kinase suppressor of ras 2, anticorps KSR2, anticorps Ksr2

Sujet:

Background:

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Ota T., Nat. Genet. 36:40-45(2004).
Scherer S.E., Nature 440:346-351(2006).
Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).

Aliases: FLJ25965 antibody, hKSR 2 antibody, hKSR2 antibody, Kinase suppressor of Ras 2 antibody, KSR 2 antibody, Ksr2 antibody, KSR2_HUMAN antibody

UniProt: Q6VAB6