ABCC5 anticorps

N° du produit ABIN7189591

Cet anticorps Lapin Polyclonal détecte spécifiquement ABCC5 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour ABCC5 anticorps (ABIN7189591)

Antigène: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABCC5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-ABCC5 anticorps

Fonction: ABCC5 Antibody

Réactivité croisée: Souris, Rat

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human ABCC5

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur ABCC5

Antigène: ABCC5 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5))

Autre désignation: ABCC5

Sujet:

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected, however, the complete sequence and translation initiation site is unclear.

Aliases: ABC 33 antibody, ABC33 antibody, ABCC 5 antibody, Abcc5 antibody, ATP binding cassette sub family C (CFTR/MRP) member 5 antibody, ATP binding cassette sub family C member 5 antibody, ATP-binding cassette sub-family C member 5 antibody, Canalicular multispecific organic anion transporter C antibody, DKFZp686C1782 antibody, EST277145 antibody, MOAT C antibody, MOAT-C antibody, MOATC antibody, MRP 5 antibody, MRP5_HUMAN antibody, Multi specific organic anion tranporter C antibody, Multi-specific organic anion transporter C antibody, Multidrug resistance associated protein 5 antibody, Multidrug resistance-associated protein 5 antibody, pABC 11 antibody, pABC11 antibody, SMRP antibody

UniProt: O15440

Pathways: Glycosaminoglycan Metabolic Process