Cullin 4A anticorps

N° du produit ABIN7190389

Cet anticorps Lapin Polyclonal détecte spécifiquement Cullin 4A dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Cullin 4A anticorps (ABIN7190389)

Antigène: Cullin 4A (CUL4A)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cullin 4A est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Cullin 4A anticorps

Fonction: CUL4A Antibody

Réactivité croisée: Souris

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human CUL4A

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Cullin 4A

Antigène: Cullin 4A (CUL4A)

Autre désignation: CUL4A

Sujet:

Background: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication.

Aliases: 2810470J21Rik antibody, AW495282 antibody, CUL 4A antibody, CUL-4A antibody, Cul4a antibody, Cul4a protein antibody, CUL4A_HUMAN antibody, Cullin-4A antibody, MGC36573 antibody, MGC64071 antibody

UniProt: Q13619