PRPS1 anticorps

N° du produit ABIN7192028

L’anticorps Lapin Polyclonal anti-PRPS1 a été validé pour WB, ELISA et IHC. Il convient pour détecter PRPS1 dans des échantillons de Humain.

Aperçu rapide pour PRPS1 anticorps (ABIN7192028)

Antigène: PRPS1 (phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRPS1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PRPS1 anticorps

Fonction: PRPS1/PRPS2/PRPS1L1 Antibody

Réactivité croisée: Souris

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human PRPS1/2/1L1

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:  pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRPS1

Antigène: PRPS1 (phosphoribosyl Pyrophosphate Synthetase 1 (PRPS1))

Autre désignation: PRPS1

Sujet:

Background: PRPS (phosphoribosyl pyrophosphate synthetase) proteins catalyze the synthesis of phosphoribosyl pyrophosphate (PRPP). Three human PRPS isoforms exist and are encoded by three different genes. PRPS1 and PRPS2 (also known as PRS1 and PRS2, respectively) are ubiquitously expressed, while PRPS3 (also known as PRPS1L1) is specific to the testis. PRPP is an important substrate synthesized from MgATP and ribose-5-phosphate in a reaction that requires inorganic phosphate and magnesium as a cofactor. PRPP is essential in the synthesis of nearly all nucleotides, implying that PRPS1/2 play an important role in nucleotide biosynthesis and purine metabolism. A mutation in the gene encoding PRPS1 may result in PRPS superactivity, a disease characterized by gout and the overproduction of purine nucleotides, uric acid and PRPP. PRPS1 mutations can also lead to a reduction in PRPS1 activity resulting in ARTS syndrome or CMTX5 (Charcot-Marie-Tooth disease X-linked recessive type 5).

Aliases: phosphoribosyl pyrophosphate synthetase 1/2/1-like 1

UniProt: P60891, P11908, P21108

Pathways: Ribonucleoside Biosynthetic Process