SRGAP1 anticorps

N° du produit ABIN7192644

Détail du produit anti-SRGAP1 anticorps

Antigène: SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRGAP1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: Antigen affinity purification

Immunogène: Synthetic peptide of Human SRGAP1

Isotype: IgG

Information d'application

Indications d'application: ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SRGAP1

Antigène: SRGAP1 (SLIT-ROBO rho GTPase Activating Protein 1 (SRGAP1))

Autre désignation: SRGAP1 (SRGAP1 Produits)

Synonymes: anticorps ARHGAP13, anticorps 4930572H05Rik, anticorps Arhgap13, anticorps RGD1566260, anticorps SLIT-ROBO Rho GTPase activating protein 1, anticorps SRGAP1, anticorps srgap1, anticorps Srgap1

Sujet:

Background: SRGAP1 contains an FCH (Fes/CIP4 homology) domain, a Rho-GAP domain and an SH3 domain. In the presence of Slit, SRGAP1 (via its SH3 domain) binds to the CC3 motif in robo (a protein responsible for mediating the repulsive effect of Slit) with higher affinity and inhibits Cdc42 activity in a robo/SRGAP-dependent manner. More specifically, SRGAP1 increases the intrinsic GTPase activity of Cdc42, thereby converting it to its inactive, GDP-bound form. Inactivation of Cdc42 µLtimately leads to a decrease in actin polymerization.

Aliases: 4930572H05Rik antibody, ARHGAP13 antibody, FLJ22166 antibody, KIAA1304 antibody, RGD1566260 antibody, Rho GTPase activating protein 13 antibody, Rho GTPase-activating protein 13 antibody, SLIT ROBO Rho GTPase activating protein 1 antibody, SLIT-ROBO Rho GTPase-activating protein 1 antibody, SRGAP 1 antibody, srGAP1 antibody, SRGP1_HUMAN antibody

UniProt: Q7Z6B7