Macrophage Scavenger Receptor 1 anticorps (AA 275-451)
-
- Antigène Voir toutes Macrophage Scavenger Receptor 1 (MSR1) Anticorps
- Macrophage Scavenger Receptor 1 (MSR1)
-
Épitope
- AA 275-451
-
Reactivité
- Humain
-
Hôte
- Souris
-
Clonalité
- Monoclonal
-
Conjugué
- Cet anticorp Macrophage Scavenger Receptor 1 est non-conjugé
-
Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Neutralization (Neut)
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human CD204 (AA: extra 275-451) expressed in E. coli.
- Clone
- 5B8H4
- Isotype
- IgG1
- Top Product
- Discover our top product MSR1 Anticorps primaire
-
-
- Indications d'application
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400, ICC: N/A, IHC: N/A
- Restrictions
- For Research Use only
-
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
-
- Antigène
- Macrophage Scavenger Receptor 1 (MSR1)
- Autre désignation
- CD204 (MSR1 Produits)
- Synonymes
- anticorps CD204, anticorps SCARA1, anticorps SR-A, anticorps SRA, anticorps phSR1, anticorps phSR2, anticorps MRS-A, anticorps MSR, anticorps MSR-A, anticorps SR-AI, anticorps SR-AII, anticorps Scara1, anticorps Scvr, anticorps MSR1, anticorps RGD1564316, anticorps macrophage scavenger receptor 1, anticorps scavenger receptor class A member 5, anticorps MSR1, anticorps Msr1, anticorps SCARA5
- Sujet
-
Description: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
Aliases: MSR1, SRA, SR-A, SR-AI, phSR1, phSR2, SCARA1, SR-AII, SR-AIII
- Poids moléculaire
- 49.8 kDa
- ID gène
- 4481
-