HAS1 anticorps (AA 74-399)

N° du produit ABIN7193521

Détail du produit anti-HAS1 anticorps

Antigène: HAS1 (Hyaluronan Synthase 1 (HAS1))

Épitope: AA 74-399

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HAS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human HAS1 (AA: 74-399) expressed in E. coli.

Clone: 2G5H6

Isotype: IgG1

Information d'application

Indications d'application: WB:1:500 - 1:2000, ELISA:1:10000,

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Détails sur HAS1

Antigène: HAS1 (Hyaluronan Synthase 1 (HAS1))

Autre désignation: HAS1 (HAS1 Produits)

Synonymes: anticorps dg42, anticorps Xhas1, anticorps HAS, anticorps shas1, anticorps hyaluronan synthase 1, anticorps hyaluronan synthase 1 S homeolog, anticorps has1, anticorps HAS1, anticorps Has1, anticorps has1.S

Sujet:

Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants.

Aliases: HAS

Poids moléculaire: 64.8 kDa

ID gène: 3036

Pathways: Glycosaminoglycan Metabolic Process