Recombinant EGFR (Cetuximab Biosimilar) anticorps

N° du produit ABIN7200654

L’anticorps anti-EGFR (Cetuximab Biosimilar) Monoclonal Souris est utilisé pour la détection de EGFR (Cetuximab Biosimilar) dans des échantillons de Humain. Il a été validé pour FACS et in vivo.

Aperçu rapide pour Recombinant EGFR (Cetuximab Biosimilar) anticorps (ABIN7200654)

Antigène: EGFR (Cetuximab Biosimilar)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp EGFR (Cetuximab Biosimilar) est non-conjugé

Application: Flow Cytometry (FACS), In vivo Studies (in vivo)

Classe de qualité: Research Grade

Clone: C225

Détail du produit anti-EGFR (Cetuximab Biosimilar) anticorps

Fonction: Cetuximab Biosimilar, Human EGFR Monoclonal Antibody

Specificité: The monoclonal antibody cetuximab biosimilar specifically binds to the human EGFR.

Attributs du produit: Cetuximab, a chimeric (mouse/human) anti-EGFR monoclonal antibody, is an EGFR inhibitor used for the treatment of metastatic colorectal cancer and head and neck cancer. Cetuximab binds to EGFR and turns off the uncontrolled growth in cancers with EGFR mutations. Cetuximab can be used for treatment of KRAS wild type colon cancer but has little or no effect in colorectal tumors harboring a KRAS mutation. Before treatment using Erbitux, it is better to do a diagnosis using the real time PCR companion diagnostic test for KRAS, the therascreen KRAS test. There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1, HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, EGFR (epidermal growth factor receptor) located on cell surface sends a signal down the MAPK pathway that includes another protein, KRAS (also spelled K-ras). Mutations affecting EGFR and/or KRAS expression or activity could result in cancer. The mutated KRAS continuously sends a growth signal to the downstream pathway, leading to uncontrollable cell division, even if EGFR has been blocked.

Purification: Protein A or G affinity column

Pureté: >95 % by reducing SDS-PAGE

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1 EU per 1 mg of the protein by the LAL method

Immunogène: The monoclonal antibody cetuximab biosimilar was produced in the cetuximab biosimilar CHO stable cell line.

Isotype: IgG1

Information d'application

Indications d'application: ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by cetuximab.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: > 3 mg/mL

Buffer: PBS, pH 7.4, no stabilizers or preservatives.

Agent conservateur: Without preservative

Stock: 4°C,-20 °C

Stockage commentaire: 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.

Date de péremption: 12 months

Détails sur EGFR (Cetuximab Biosimilar)

Antigène: EGFR (Cetuximab Biosimilar)

Autre désignation: Cetuximab Biosimilar

Classe de substances: Biosimilar