Recombinant Ranibizumab Biosimilar anticorps

N° du produit ABIN7200657

L’anticorps Humanized Monoclonal anti- a été validé pour FACS et in vivo. Il convient pour détecter dans des échantillons de Humain.

Aperçu rapide pour Recombinant Ranibizumab Biosimilar anticorps (ABIN7200657)

Antigène: Ranibizumab Biosimilar

Type d'anticorp: Recombinant Antibody

Fragment: Fab fragment

Reactivité: Humain

Hôte: Humanized

Clonalité: Monoclonal

Application: Flow Cytometry (FACS), In vivo Studies (in vivo)

Classe de qualité: Research Grade

Détail du produit

Fonction: Ranibizumab Biosimilar, Human VEGF Monoclonal Antibody Fragment (Fab)

Specificité: The Fab protein ranibizumab specifically binds to the human VEGF-A.

Attributs du produit: The humanized anti-VEGF-A monoclonal antibody drug Bevacizumab (trade name Avastin, Genentech/Roche) is the first clinically available angiogenesis inhibitor in the United States. The humanized anti-VEGF-A monoclonal antibody fragment (Fab) Ranibizumab (trade name Lucentis, Genentech) is derived from the same parent mouse antibody as bevacizumab. Both antibody drugs produce angiogenesis inhibition and slow the growth of new blood vessels. Ranibizumab is much smaller than the parent complete antibody but shows stronger binding to VEGF-A after affinity maturation. Ranibizumab can also be used to treat the "wet" type of age-related macular degeneration (AMD, also ARMD), a common form of age-related vision loss. Vascular endothelial growth factor A (VEGF-A) stimulates angiogenesis in a variety of cancers, including colorectal, lung, breast, glioblastoma, kidney, and ovarian cancers.

Purification: Protein A or G affinity column

Pureté: >95 % by reducing SDS-PAGE

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 1 EU per 1 mg of the protein by the LAL method

Immunogène: The research grade Fab protein ranibizumab was produced in the ranibizumab biosimilar E.coli cell line.

Isotype: IgG1

Information d'application

Indications d'application: Functional assay, neutralization.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: > 3 mg/mL

Buffer: PBS, pH 7.4, no stabilizers or preservatives.

Agent conservateur: Without preservative

Stock: 4°C,-20 °C

Stockage commentaire: 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.

Date de péremption: 12 months

Détail du antigène

Antigène: Ranibizumab Biosimilar

Classe de substances: Biosimilar