HAAO anticorps (AA 30-110)

N° du produit ABIN7227096

L’anticorps anti-HAAO Polyclonal Lapin est utilisé pour la détection de HAAO dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et ELISA.

Aperçu rapide pour HAAO anticorps (AA 30-110) (ABIN7227096)

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAAO est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HAAO anticorps

Épitope: AA 30-110

Fonction: Rabbit Anti-3HAO Polyclonal Antibody

Specificité: The antibody detects endogenous levels of 3HAO protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human 3HAO protein at AA range: 30-110

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur HAAO

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Autre désignation: 3HAO

Sujet: 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilate oxygenase, 3-HAO, 3-hydroxyanthranilic acid dioxygenase, HADHAAO (3-Hydroxyanthranilate 3,4-Dioxygenase) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of tryptophan utilization. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

Poids moléculaire: 31kD

ID gène: 23498

UniProt: P46952