ESRRG anticorps (AA 61-160) (Biotin)

N° du produit ABIN715828

Cet anticorps Lapin Polyclonal détecte spécifiquement ESRRG dans WB, ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour ESRRG anticorps (AA 61-160) (Biotin) (ABIN715828)

Antigène: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ESRRG est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ESRRG anticorps (Biotin)

Épitope: AA 61-160

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ESRRG/Estrogen Related Receptor gamma

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur ESRRG

Antigène: ESRRG (Estrogen-Related Receptor gamma (ESRRG))

Autre désignation: Estrogen Related Receptor gamma

Sujet:

Synonyms: ERR 3, ERR G2, ERR gamma 2, ERR gamma-2, ERR3, ERR3_HUMAN, ERRG 2, ERRG2, ESRRG, Estrogen receptor related protein 3, Estrogen receptor-related protein 3, Estrogen-related receptor gamma, NR3B3, Nuclear receptor subfamily 3 group B member 3.

Background: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors, they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region.

ID gène: 2104

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway