BCAS2 anticorps (AA 150-230)

N° du produit ABIN7213778

Cet anticorps anti-BCAS2 est un anticorps Lapin Polyclonal détectant BCAS2 dans WB et ELISA. Adapté pour Humain, Souris, Rat et Singe.

Aperçu rapide pour BCAS2 anticorps (AA 150-230) (ABIN7213778)

Antigène: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BCAS2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-BCAS2 anticorps

Épitope: AA 150-230

Fonction: BCAS2 Polyclonal Antibody

Specificité: BCAS2 Polyclonal Antibody detects endogenous levels of BCAS2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from the C-terminal region of human BCAS2 at AA range: 150-230

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur BCAS2

Antigène: BCAS2 (Breast Carcinoma Amplified Sequence 2 (BCAS2))

Autre désignation: BCAS2

Sujet: Rabbit Anti-BCAS2 Polyclonal Antibody,BCAS2, DAM1, Pre-mRNA-splicing factor SPF27, Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Spliceosome-associated protein SPF 27,BCAS2 was identified through differential display analysis as an mRNA species that was overexpressed in MCF7 and BT-20 breast cancer cell lines. The chromosomal region containing this gene, 1p13.3021, is amplified in these cells lines. BCAS2 is a transcriptional cofactor that enhances estrogen receptor-mediated gene expression, and directly interacts with the tumor suppressor p53 to reduce p53 transcriptional activity by reducing p53 protein level in the absence of DNA damage. Deprivation of BCAS2 through RNA inhibition induces apoptosis in p53-wild type cells, but causes G2-M arrest in p53- or -mutant cells, this effect was reversed with the expression of ectopic BCAS2. BCAS2 may thus be potentially useful as a therapeutic target in the treatment of cancer.,Pre-mRNA-splicing factor SPF27

ID gène: 10286

UniProt: O75934