CAGE1 anticorps (AA 680-760)

N° du produit ABIN7213916

L’anticorps anti-CAGE1 Polyclonal Lapin est utilisé pour la détection de CAGE1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour ELISA, WB, IHC et IF.

Aperçu rapide pour CAGE1 anticorps (AA 680-760) (ABIN7213916)

Antigène: CAGE1 (Cancer Antigen 1 (CAGE1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CAGE1 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-CAGE1 anticorps

Épitope: AA 680-760

Fonction: Rabbit Anti-CAGE-1 Polyclonal Antibody

Specificité: CAGE-1 Polyclonal Antibody detects endogenous levels of CAGE-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the C-terminal region of human CAGE-1 at AA range: 680-760

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CAGE1

Antigène: CAGE1 (Cancer Antigen 1 (CAGE1))

Autre désignation: CAGE-1

Sujet: CAGE1, CTAG3, Cancer-associated gene 1 protein, CAGE-1, Cancer/testis antigen 3, CT3CAGE (cancer-associated gene protein), also known as DEAD box protien 53 (DDX53) or DEAD box protein CAGE, belongs to the DEAD box helicase family. It contains one helicase ATP-binding domain, one helicase C-terminal domain and one KH domain. CAGE localizes to the nucleus and, in normal adult tissues, is exclusively expressed in testis but it has also been found in a wide variety of cancer tissues and cell lines. Overexpression of CAGE leads to the activation of FAK, ERK and p38 MAPK along with a reduction in reactive oxygen species (ROS). It is also responsible for inducing catalase activity and therefore enhancing cell motility. This suggests that CAGE may enhance the migration of cancer cells. In addition, hypomethylation of the CAGE promoter region is associated with tumor progression and may serve as a valuable marker in cancer diagnosis.

Poids moléculaire: 90kD

ID gène: 285782

UniProt: Q8TC20