CIC anticorps (AA 550-630)

N° du produit ABIN7227904

Cet anticorps anti-CIC est un anticorps Lapin Polyclonal détectant CIC dans WB et ELISA. Adapté pour Souris et Humain.

Aperçu rapide pour CIC anticorps (AA 550-630) (ABIN7227904)

Antigène: CIC (Capicua Homolog (CIC))

Reactivité: Souris, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CIC est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CIC anticorps

Épitope: AA 550-630

Fonction: CIC Polyclonal Antibody

Specificité: The antibody detects endogenous levels of CIC protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogène: Synthesized peptide derived from part region of human CIC protein at AA range: 550-630

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur CIC

Antigène: CIC (Capicua Homolog (CIC))

Autre désignation: CIC

Sujet: Rabbit Anti-CIC Polyclonal Antibody,Protein capicua homolog,CIC encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID: 6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID: 21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID: 100288687) and FOXO4 (GeneID: 4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.,CIC

Poids moléculaire: observerd band 176kDa

ID gène: 23152

UniProt: Q96RK0