CIC anticorps (AA 550-630)

N° du produit ABIN7227904

Cet anticorps anti-CIC Polyclonal Lapin (ABIN7227904) détecte spécifiquement CIC dans WB et ELISA. L’anticorps est réactif avec des échantillons de Souris et Humain.

Aperçu rapide pour CIC anticorps (AA 550-630) (ABIN7227904)

Antigène: CIC (Capicua Homolog (CIC))

Reactivité: Souris, Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CIC est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-CIC anticorps

Épitope: AA 550-630

Fonction: Rabbit Anti-CIC Polyclonal Antibody

Specificité: The antibody detects endogenous levels of CIC protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human CIC protein at AA range: 550-630

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CIC

Antigène: CIC (Capicua Homolog (CIC))

Autre désignation: CIC

Sujet: Protein capicua homologCIC encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID: 6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID: 21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID: 100288687) and FOXO4 (GeneID: 4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 176kD

ID gène: 23152

UniProt: Q96RK0